Cotinine (COT) Rapid Tests

The COT Rapid Test is a rapid chromatographic immunoassay for the detection of Cotinine in human urine/saliva. This test will detect other related compounds, please refer to the Analytical Specificity table in this package insert.


  • Description
  • Specifications
  • 【SUMMARY】


    Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays. In a 24-hour urine, approximately 5% of a nicotine dose is excreted as unchanged drug with 10% as cotinine and 35% as hydroxycotinine; the concentrations of other metabolites are believed to account for less than 5%.1 While cotinine is thought to be an inactive metabolite, it’s elimination profile is more stable than that of nicotine which is largely urine pH dependent. As a result, cotinine is considered a good biological marker for determining nicotine use. The plasma half-life of nicotine is approximately 60 minutes following inhalation or parenteral administration.2 Nicotine and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in urine at a cutoff level of 500 ng/mL is expected to be up to 2-3 days after nicotine use


    Order Information


    Cat. No.

    Product

    Specimen

    Format

    PackCut-off

    DCOT-S11

    COT Test Strip

    Urine

    Strip

    50T

    100,

    200,

    ng/ml

    DCOT-C11

    COT Test Cassette

    Urine

    Cassette

    25T

    DCOT-P11

    COT Test Panel

    Urine

    Panel

    25T

    DCOT-C81

    COT Test Cassette

    Saliva

    Cassette

    25T

    30,50

    ng/ml




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